2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0294S
    Flubendazole-d3
    		Inhibitor
    Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle.
    Flubendazole-d<sub>3</sub>
  • HY-B0828R
    Triazophos (Standard)
    Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
    Triazophos (Standard)
  • HY-168918
    Insecticidal agent 19
    		Inhibitor
    Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM.
    Insecticidal agent 19
  • HY-D0143AR
    Quinine dihydrochloride (Standard)
    		Inhibitor
    Quinine (dihydrochloride) (Standard) is the analytical standard of Quinine (dihydrochloride). This product is intended for research and analytical applications. Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
    Quinine dihydrochloride (Standard)
  • HY-108251R
    Methotrexate metabolite (Standard)
    Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite (Standard)
  • HY-13735H
    Quinacrine acetate
    		Inhibitor
    Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment.
    Quinacrine acetate
  • HY-W738358
    Chlorproguanil hydrochloride
    		Inhibitor
    Chlorproguanil (hydrochloride) is an antimalarial drug. Chlorproguanil (hydrochloride) is a dichloro-derivative of chloroguanide.
    Chlorproguanil hydrochloride
  • HY-B0177R
    Tinidazole (Standard)
    Tinidazole (Standard) is the analytical standard of Tinidazole. This product is intended for research and analytical applications. Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa.
    Tinidazole (Standard)
  • HY-126417
    Methylenetanshinquinone
    		Inhibitor
    Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection.
    Methylenetanshinquinone
  • HY-146488
    Anti-infective agent 2
    		Inhibitor
    Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL.
    Anti-infective agent 2
  • HY-149958
    Antileishmanial agent-17
    		Inhibitor
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-125298
    Cycloaspeptide A
    		Inhibitor
    Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity.
    Cycloaspeptide A
  • HY-149810
    AcrB-IN-2
    		Inhibitor
    AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.
    AcrB-IN-2
  • HY-169289
    PIQ-2
    		Inhibitor
    PIQ-2 (compound 54) is a antiprotozoal agent with the IC50 values of 9.4 nM and 1.6 nM against IP. falciparum 3D7I and B. divergens Rouen,respectively.
    PIQ-2
  • HY-N8465
    Noracronycine
    		Inhibitor
    Noracronycine is an alkaloid originally isolated from G. pentaphylla that has antimalarial activity. It is active against P. yoelii when used at a concentration of 10 μg/mL.
    Noracronycine
  • HY-B0846S
    Dimethomorph-d8
    Dimethomorph-d8 is the deuterium labeled Dimethomorph. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM.
    Dimethomorph-d<sub>8</sub>
  • HY-163560
    Insecticidal agent 10
    		Inhibitor
    Insecticidal agent 10 (Compound 8c) is an inhibitor for chitinase, which inhibits OfChi-h and OfChtI with IC50 of 1.51 and 9.21 nM, respectively. Insecticidal agent 10 inhibits growth of Ostrinia furnacalis with LC50 of 22.14 mg/L.
    Insecticidal agent 10
  • HY-168184
    WJM280
    		Inhibitor
    WJM280 is an orally active antimalarial agent, with an EC50 of 0.04 μM for P. falciparum 3D7 parasites.
    WJM280
  • HY-17589S
    Chloroquine-d5 diphosphate
    		Inhibitor
    Chloroquine-d5 (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
    Chloroquine-d<sub>5</sub> diphosphate
  • HY-131433
    Teroxalene hydrochloride
    		Inhibitor
    Teroxalene hydrochloride is an orally active schistosomiasis agent.
    Teroxalene hydrochloride
Parasite Isoform Comparison

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